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First, this study was conducted in males since we have previously shown that adolescent nicotine enhancement of cocaine self-administration is seen in both males and females ( 4.4 Clinical Implications With increasing evidence that aberrant activation of 5-HT systems during adolescence triggers lasting changes in neuronal signaling, use of drugs such as tobacco, e-cigarettes, and antidepressants may permanently alter the course of adolescent brain maturation and neurotransmitter signaling

We posed three research questions: 1) Which women are more likely to continue smoking during pregnancy?, 2) What is the most frequent reason for smoking cessation during pregnancy?, 3) What is the most frequent reason to continue smoking during pregnancy

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