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Keywords: osteoarthritis, cigarette smoking, electronic cigarette, synovitis, immune dysregulation, inflammasome, NF-B, microRNA Introduction Osteoarthritis (OA) is a major cause of chronic pain and disability around the world, and it has become an increasing public health problem

"That is why, alongside new measures to curb the alarming rise in youth vaping, we are delivering on our commitment to create a smoke-free generation and stop our kids from getting hooked on harmful cigarettes and other nicotine products." England's chief medical officer, Professor Chris Whitty, said: "If passed this will be a major public health measure which reduce illness, disability, and premature deaths for children today and future generations

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