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Smoking demonstrates a direct causal relationship with COPD development, as tobacco smoke damages lung airways, reduces oxygen exchange capacity, and triggers chronic inflammation that progressively worsens breathing function

doi: 10.1046/j.1365-2141.1997.d01-2137.x

See Supplementary Tables 4 and 7 for study bias characteristics and selected bias covariates, Supplementary Fig

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Those taking such medications should pay extra attention to oral hygiene, go for regular dental check-ups and identify any abnormalities in the mouth early