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Using reduced and oxidized glutathione, you can refold this protein into a more compact and more energetically favorable protein on the right where the disulfide bond is now between the first and third cysteine residues Glutathione is important in maintaining redox balance in cultured cells, and is already included in many formulations of cell media (Ishii & Mann, 2014)

On the other hand, extrinsic apoptosis is mediated by different molecules and ligands such as TNFR1-TNF, FAS-FasL, and TRAIL-DR4/DR5

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Based on the amphiphilic nature, the polymer can self-assemble into tumor-targeting nanoreactors