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It melted twelve thousand years ago in Wisconsin and Maine

The tobacco belt of south-western Ontario was a motor of prosperity in the mid-20th century, having helped Canada out of the depression in the late 1920s, but in recent decades the crop has been discouraged and the government has bought out some farmers

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According to a spokeswoman for Pfizer, the drug company used a double-blind random placebo-controlled trial which she suggested was more robust in evaluation of success