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Two critical events converged: The Health Scare: In 1952, Reader's Digest published a landmark article titled "Cancer by the Carton," linking smoking to lung cancer

This study also adds to existing evidence suggesting that the proportion of new schizophrenia cases that may be attributed to cannabis use disorder has consistently increased over the past five decades

Usually the brain responds to loss of energy with hunger, but smoking disrupts this pathway and makes use of the body's fat storage instead, leading to weight loss and possibly malnutrition

We performed association analyses with lung cancer, as controlling for smoking status is crucial in these models