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How Long Does Nicotine Stay in Your System? Phoenix Rising What Happens to Your Body, When You Take a Puff of a Cigarette? Keck Medicine of USC Did you know that your body will start to recover from damage caused by smoking about 20 minutes after your last cigarette? Once you quit smoking your body starts to repair the Quitting tobacco has immediate and long term benefits for your health. Every step away from smoking helps your body heal. 20 minutes: Heart rate drops 12 hours: Carbon monoxide levels return What happens to your body after quitting smoking
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