Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-MMAE Size:25mg CC-885 promotes degradation of GSPT1

CC-885 promotes degradation of GSPT1

411 SMILES OCCCCCCC1=CC=C2C(=O)N(CC2=C1)C1CCC(=O)NC1=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

891 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCCOCCOCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Lenalidomide-PEG6-propargyl Synonyms Lenalidomide-4'-PEG6-propargyl CAS Number n/a Related CAS Molecular Formula C28H39N3O9 Molecular Weight 561

The water soluble 5-FAM PEG3 azide has a long PEG3 spacer that separates the dye carboxyfluorescein (commonly known as FAM) from the terminal azide group

Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-MMAE Size:25mg CC-885 promotes degradation of GSPT1SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly