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The double role of AMPK in controlling both mTORCs clarifies new opportunities for targeted treatment approaches in several cancers is illustrated in (Fig

When normal human lung bronchial epithelial cells are exposed to Cu 2+ , RNA microarray analysis has shown increased expression of heat shock response, ubiquitin-related, and autophagy-regulated genes

This assessment was undertaken due to copper known impact on ferroptosis sensitivity 26 , mediated in part by the transcriptional activity of NFE2L2

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A cellular perspective on brain energy metabolism and functional imaging