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doi: 10.1371/journal.pone.0191866 7 LeeBEChoiBYHongDKKimJHLeeSHKhoARet al

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Moreover, in attempts to replace the hydroxyl group of the tyrosine moiety to avoid potential problems with phase II metabolism compound 27 was prepared (Barlow et al., 2020)

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The key difference is that retatrutide provides triple agonism (GLP-1 + GIP + glucagon) while semaglutide provides only GLP-1 agonism

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