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10.1038/nature13479 Nature

Ferwana, M

In ALS (amyotrophic lateral sclerosis), GPx4 depletion is present in the spinal cord of both sporadic and familial patients and it is an early and prevalent feature in the spinal cord and brain of ALS mouse models such as SOD1G93A (Superoxide dismutase 1G93A), TDP-43, and C9 or f72, GPx4 depletion and ferroptosis are associated with impaired NRF2 signaling, glutathione synthesis and dysregulation of iron binding proteins