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Breathlessness: Feeling winded after minor exertion due to a lack of healthy red blood cells to carry oxygen

This disparity underscores a critical knowledge gap that must be resolved before confident, evidence-based clinical adoption can be justified

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dose-dependent GI adverse events (nausea, vomiting) similar to other amylin analogues Exposure: Dose-proportional increases in Cmax and AUC Gastric Effects: Dose-dependent slowing of gastric emptying confirmed via paracetamol absorption test Appetite Suppression: Reduced ad libitum food intake at doses 1.2 mg Clinical Significance: Established feasibility of once-weekly dosing and identified dose range for Phase 2 studies