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Apart from investigation mentioned in individual cases and in table, all patients underwent other investigations like renal function test, liver function test, serum electrolytes, HIV ELISA, thyroid profile, which came out to be normal in all patients

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IFD foci depend on MTs and dynein motors for formation Under high proteostress conditions, ubiquitinated and non-ubiquitinated aggregated proteins in mammalian (and other) cells can be linked to adaptors such as HDA-6/HDAC6, SQST-1/p62, and the HSP-1/Hsc70/BAG3/FTT-2/14-3-3 complex, which connect to dynein motors and move along microtubule tracks to juxtanuclear sites to deposit aggregate cargos 26,27,28 (summary diagram in Fig

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