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Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Evidence of a Novel Mitochondrial Signature in Systemic Sclerosis Patients with Chronic Fatigue Syndrome Oxidative stress is a shared characteristic of ME CFS and Long COVID PNAS ME CFS: Mitochondrial Dysfunction, Autoimmunity & Dysautonomia Myalgic Encephalomyelitis Chronic Fatigue Syndrome: the biology of a neglected disease PMC
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