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K.KagawaY.EbrahimiM.YamamotoY.et al (2016)

S.BahalR.FarrellyJ

Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice

Moreover, the application of AI/ML as well as xAI to move beyond the limitations of black-box data-driven models is an accelerating trend, not only in biomedical fields 57,58 such as drug and cancer diagnostics but also emerging in bioprocess modeling 59

Most therapeutic interventions remain in preclinical development, with clinical translation hindered by two key barriers: The lack of validated biomarkers for patient stratification and incomplete elucidation of synergistic combination mechanisms