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Many bioactive compounds exhibit antioxidant, anti-inflammatory, hormone-modulating, and barrier-stabilizing properties, providing a biologically plausible foundation for nutritional interventions (Figure 2)

In addition, bacteria-derived LPS increases Toll-like receptor 4 (TLR4) activity and activates downstream NF-B signaling to promote inflammation and barrier dysfunction 69

In a Brazilian RCT with 67 participants suffering unipolar and bipolar depression, NAC dramatically reduced CRP throughout the course of 12 weeks when compared to a placebo

Application of HSAB principles (soft-soft interactions) combined with knowledge of physicochemical parameters (e.g., pKa, steric hindrance) has led to the concept of enolate-based cytoprotection as well as a detailed understanding of molecular mechanism