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Science 265:742743 Additional information Correspondence to: S.I

Metformin plus temozolomide-based chemotherapy as adjuvant treatment for WHO grade III and IV malignant gliomas

Moreover, almost all authors who worked on genotoxicity assays have reported positive genotoxic effects of CQ in multiple test systems

All experiments in this study were repeated independently with similar results at least three times to ensure credible results and statistical validity