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Rarely reported symptoms associated with excessive B12 intake may include: Skin reactions : Acne-like eruptions or rosacea-type dermatitis have been occasionally reported, particularly with high-dose intramuscular injections Gastrointestinal disturbance : Mild nausea, diarrhoea, or abdominal discomfort, though these are uncommon Headache : Infrequent reports of headaches following parenteral B12 administration Hypersensitivity reactions : In very rare cases, allergic reactions to injectable B12 preparations have been documented It is crucial to note that there is no established link between standard B12 supplementation and serious adverse effects

Cells co-treated with metformin and compound C exhibited upregulated GLUT1 expression and downregulated TXNIP expression compared with the control (Supplementary Fig

Another study found that NAC treatment reduced myocardial ischemia-reperfusion injury in diabetic rats, suggesting its potential for treating human cardiac conditions (209)

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