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The classic example is sickle cell trait, where heterozygous carriers possess a survival advantage against severe malaria infections

Notably, the nervous system is no longer viewed as a passive responder in psoriatic inflammation, but rather as an active regulatory hub that orchestrates the dissemination of key inflammatory mediatorssuch as IL-17 A, IL-1, and TNF-and governs neuro-sensitization

Redox-mediated post-translational modifications (PTMs) constitute a significant group of PTMs that specifically affect the thiol group of cysteine residues