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For researchers dedicated to uncovering the true potential of compounds like this, navigating these nuances isn't a burdenit's the very essence of the work

We found that a minimal motif of two histidine residues joined by a few glycine residues is sufficient to generate ROS at two and a half times the rate of the corresponding A complex

This caution is also relevant to individuals with pre-existing acid base abnormalities, recurrent metabolic alkalosis, chronic respiratory disease with renal compensation, prolonged vomiting, gastric fluid loss, or conditions requiring loop or thiazide diuretics