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The concentration of S2635 or S2782 that killed 50% of spirochetes (EC 50 ) was calculated using dose-response stimulation fitting in GraphPad Prism 9.3.1

In the erlotinib-treated HT22 hippocampal neuron model, CHY enhanced GPX4 expression, reduced ACSL4, suppressed ROS, and improved cell viability, further supporting its role in ferroptosis regulation (Shang JF

[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Martnez-Mndez D, Huerta L, Villarreal C

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There are two variations of the suggested mechanism depending on whether the first GSH molecule attacks the Grx(SSR) intermediate at the sulfur atom of the glutaredoxin 60 or the substrate 15,30