Azide-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg Product Name Phthalimidinoglutarimide-C3-O-PEG4-OH Synonyms Phthalimidinoglutarimide-4'-C3-O-PEG4-OH

Product Name Phthalimidinoglutarimide-C3-O-PEG4-OH Synonyms Phthalimidinoglutarimide-4'-C3-O-PEG4-OH CAS Number n/a Related CAS Molecular Formula C24H34N2O8 Molecular Weight 478

hydroxyethoxy)

483 Purity (HPLC) >= 95% Solubility DMSO

SPAAC is copper-free

411 SMILES OCCCCCCC1=CC=C2C(=O)N(CC2=C1)C1CCC(=O)NC1=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Azide-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg Product Name Phthalimidinoglutarimide-C3-O-PEG4-OH Synonyms Phthalimidinoglutarimide-4'-C3-O-PEG4-OHSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC