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10.1038/nature10956 Nature 31 LiH.FischleW.WangW.DuncanE

Among the remaining 111 articles that were initially deemed eligible, 66 were excluded due to unavailable full-text, absence of untreated or placebo-treated control group, non-RCT study design, not extractable data or presence of fertile men in the control group

The key feature of ferroptosis is the accumulation of lipid hydroperoxide, resulting from a decrease in glutathione peroxidases (GPXs)

Based on another RCT, a single dose of B12 (500 g/d) or its combination with B1(300 mg/d), B6 (80 mg/d), and B9 (2mg/d) during 12 weeks had favorable effects on the frequency of headache attacks and migraine disability (73)