Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE protac ligand 446 SMILES CC(C)(C)OC(=O)NCCN1CCN(CCOCCN)CC1 Purity (HPLC)

446 SMILES CC(C)(C)OC(=O)NCCN1CCN(CCOCCN)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

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The water soluble 5(6)-TAMRA PEG3 azide has a long PEG3 spacer that separates the dye tetramethylrhodamine (commonly known as TMR or TAMRA) from the terminal azide group

Product Name Thalidomide-5'-piperazine-PEG1-C2-amine HCl Synonyms CAS Number n/a Related CAS Molecular Formula C21H29Cl2N5O5 Molecular Weight 502

Product Name Thalidomide-O-C3-Br Synonyms Thalidomide-4'-O-C3-Br CAS Number n/a Related CAS Molecular Formula C16H15BrN2O5 Molecular Weight 395

Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE protac ligand 446 SMILES CC(C)(C)OC(=O)NCCN1CCN(CCOCCN)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to