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[38] In consequence, Japanese individuals homozygous or, to only a slightly lesser extent, heterozygous for glu487lys metabolize ethanol to acetaldehyde normally but metabolize acetaldehyde poorly and are susceptible to a set of adverse responses to the ingestion of, and sometimes even the fumes from, ethanol and ethanol-containing beverages

That's well below toxic thresholds, but chronic administration over 6+ months hasn't been studied in controlled human trials

It is studied for its selective action on lipolytic pathways without activating the IGF-1 receptor

(2024) Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models