Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-MMAE Size:1mg Chloropyrimidine (CP) derivatives generally exhibit

Chloropyrimidine (CP) derivatives generally exhibit better cell permeability compared to their benzylguanine (BG) derivatives

836 SMILES: [O-]C(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCCOCCOCCOCC#C Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

823 Purity (HPLC) >= 95% Solubility DMSO

Product Name DOTA-PEG1-propargyl Synonyms CAS Number n/a Related CAS Molecular Formula C21H35N5O8 Molecular Weight 485

… Abu-Yousif

Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-MMAE Size:1mg Chloropyrimidine (CP) derivatives generally exhibitSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly