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Int J Mol Sci 25(3):1755 Zhang L et al (2023) HDAC3 aberration-incurred GPX4 suppression drives renal ferroptosis and AKI-CKD progression

doi: 10.1111/j.1462-5822.2011.01682.x 80 SkellyDTHennessyEDansereauMACunninghamC

Metformin has been shown to reduce the accumulation of AGEs in the sciatic nerves of rats with streptozotocin (STZ)-induced diabetes by activating AMPK, leading to improved nerve conduction velocity, and the attenuation of heat and mechanical hyperalgesia (59)

There appears to be a dose effect for physical activity and weight loss, and much greater amounts of exercise are necessary to produce significant weight loss in the absence of a calorically restricted diet