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Other genes, such as GPAT1 , GPAT2, APAT4 , CPT2, ACC1 , ACSL1 , ACSL4 , FATP1 , FATP3 , FATP4 , and FATP6 , were not significantly altered

Because the concentration of PQ in the brain following acute exposure is low, the possibility of neurotoxicity by PQ was overlooked in earlier studies as it was thought that the blood-brain barrier (BBB) would impede PQ entry into the brain

But reduced production tells only half the story

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Notably, upregulation of serpinA3N was found in AD model mice (Han et al., 2024)