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The chain of antioxidant protection depends on glutathione sitting at the base

The flies solely administered with L-DOPA performed better during initial exposure after which their progress declined, consistent with the reported pattern of wearing-off in L-DOPA administered PD patients 39,55

Such a metabolic landscape suggests that HGSC depends on cystine uptake to counteract high levels of iron-dependent oxidative stress and maintain redox homeostasis, thereby preventing ferroptosis-induced cell death [16]