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European Journal of Pharmacology , 570(13), 212221

How it works: Kisspeptin-10 binds to the KISS1R receptor (also called GPR54) on GnRH-secreting neurons in the hypothalamus

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Biotin and B12 in the B12 form of adenosylcobalamin work as a coenzyme in two directly successive metabolic steps: the biotin-dependent reaction provides the starting substance for the B12-dependent reaction (1, 2)