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The 16 leukemia cell lines were derived from patients with high-risk disease including infants with KMT2A -r leukemia, one of the poorest outcome pediatric leukemias, T-ALL, mixed phenotype acute leukemia (MPAL), and CALM-AF10 translocated AML (Supplementary Table 1)

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Binding of glutamate changes the receptors conformation and allows influx of extracellular Na + and other cations, and an efflux of intracellular K + ions