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During these stages, alterations in nutritional, hormonal and the environment can promote morphological and functional adjustments that may increase the predisposition to development of diseases throughout life ( Early postnatal overfeeding model, induced by litter size reduction, causes changes in brown adipose tissue (BAT), reducing the expression of transcriptional regulators, such as PPAR (peroxisome proliferator-activated receptor gamma) and C/EBP (CCAAT/enhancer binding proteins), and reducing lipase, sympathetic 3-adrenergic receptor, and UCP-1 (uncoupling protein 1) gene expression on PND60 ( Adolescence represents a period of accelerated growth, characterized by increased nutritional requirements, physiological increases in adipose tissue, and enhanced consumption of fast food ( Although obesity in childhood and adolescence has been increasing significantly in recent years, studies have shown that current strategies for obesity management in this age group are ineffective, showing the importance of searching for new treatment alternatives ( Citrus aurantium L

[DOI] [PMC free article] [PubMed] [Google Scholar] 109.Andrich D.E., Melbouci L., Ou Y., Auclair N., Mercier J., Grenier J.-C., Lira F.S., Barreiro L.B., Danialou G., Comtois A.-S., et al