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Participants In the present study, we focus on families of substances, namely patients who entered treatment for alcohol use disorders (AUD, n=607122), opioid use disorders (OUD: heroin, fentanyl and others, n=283381), or stimulant use disorders (StUD: powder cocaine, crack cocaine, ecstasy/MDMA, (meth)amphetamines, synthetic cathinones, others, n=57189) (see Supplementary file Table 1 for details on the samples)

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In addition, there has been a rise in the vaping of non-nicotine substances, such as tetrahydrocannabinol (THC) and cannabidiol (CBD)

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