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the change in the number of nocturia episodes per 24 hours was -21.7 (p=0.001) and -1.51.8 (p=0.003) and the mean voided volume improved from 95 to 176 mL, and from 99 to 174 mL in those with and without nocturnal polyuria, respectively

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This is the study most frequently cited by GHK-Cu proponents and it is a legitimate, controlled comparison showing superiority over two established topical treatments

doi: 10.1016/J.BBIOSY.2024.100090 128 ParkMKimDKoSKimAMoKYoonH

One placebo-controlled trial of 4.5 mg LDN nightly showed statistically significant improvements in mental health and pain scales.[ref] However, another placebo-controlled trial, though, showed no statistical difference between LDN and placebo in MS patients.[ref] In a review of six trials of LDN in MS, four out of six had positive results.[ref] LDN for pain and fibromyalgia: At low doses, naltrexone has a pain-relieving effect