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Eukaryotic cells have developed complex metabolic strategies to severely restrict deuterium levels in the mitochondria, due to the fact that it damages the ATPase pumps, which produce adenosine triphosphate (ATP), the energy currency of the cell (Olgun, 2007

We first studied hyperpolarized [1- 13 C]dehydroascorbate in the normal rat brain, demonstrating its robust conversion to [1- 13 C]vitamin C, consistent with rapid transport of the oxidized form across the blood-brain barrier

402,403,404 By modulating PPAR/TRPC1/TRPC6 expression or inhibiting Notch3 signaling, sildenafil effectively mitigated PASMCs proliferation and HPVR, alleviating right ventricular pressure/hypertrophy