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Simental-Mendia 2014)

The thalidomide-binding domain of cereblon defines the CULT domain family and is a new member of the -tent fold

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Notably, the proportion of intra-thyroidal and extra-thyroidal T3 production is not fixed, as often falsely assumed, but adapts to different conditions [3]

Instead of focusing on single genes, considerable emphasis has been placed on utilizing data-driven frameworks at the system or network level to generate biologically/clinically meaningful gene modules comprising sets of functionally associated genes whose homeostasis may be altered by specific pathophysiological events[1519]