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At the same time, the higher concentration of LPS in the serum might promote the inflammation in the colon of mice from the EpCAM +/ + DSS group through TLR4-ER stress-p38 pathway

Semaglutide's SELECT trial demonstrated cardiovascular benefits, setting a new standard

Although there is no evidence of direct SIRT1 agonism, urolithin A is a well described mitophagy activator (63, 66, 67), contributing to improved mitochondrial efficiency and redox balance, which can indirectly improve SIRT1 expression and activity (68)

doi: 10.1186/s13018-022-03308-w 99 ZhouX.ZhangN.ZhangJ.GuQ.DongC.LinB.et al

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