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FIGURE 6 FIGURE 7 Discussion GHK, a human tripeptide, natural and non-toxic, exhibits extraordinary effects with anti-inflammatory and neuroprotective effects in acute lung injury ( Intracerebral hemorrhage injury mainly results from the secondary injury followed hematoma formation including hemoglobin cytotoxicity and explosive inflammatory response, which mainly resulted in brain edema and neuron death ( Accumulating evidence revealed that astrocytes play various homeostatic roles in the brain ( Several studies of stroke have demonstrated that signal pathways regulate AQP4 expressions, such as the MAPK pathway and NF-B pathway ( 2 O 2 stimulated PC 12 cells

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doi: 10.1016/s1386-6532(99)00079-7 86 ApostolouERizwanMMoustardasPSjgrenPBertilsonBCBrageBet al

10.1016/j.chembiol.2006.08.005 267 WickramaratneA