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The mechanism involves iron overload suppressing the expression of bone formation-related transcription factors, including runt-related transcription factor 2 (RunX2), osteocalcin (OCN), and alkaline phosphatase (ALP), which subsequently reduces SLC7A11/GPX4 levels and ultimately induces ferroptosis (Figure 1)

Type 1 diabetes mellitus (T1DM), also known as insulin-dependent diabetes, is characterized by the autoimmune destruction of pancreatic beta cells, leading to a complete deficiency of insulin and resulting in chronic hyperglycemia (see Figure 1 )

Herbal medicine is a major alternative to allopathic treatments, but only a few herbal drugs are scientifically validated, and poor regulation in many countries raises safety and quality concerns

What escalation or measurement mistakes matter

At the same time, two oral drugs, Deferiprone (DFP) and Deferasirox (DFX) , have been developed to address the short half-life of DFO , but side effects such as granulocyte deficiency (Lecornec et al., 2022)and renal failure (Kattamis, 2019)are still present during treatment