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The proposal to modify the current diagnostic criteria also derives from the observation that in 15 out of 16 patients of our cohort who did not satisfy the major criterion 1 (and consequently neither the minimal criteria for genetic testing), this was due to the absence of generalized skin hyperextensibility

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Assessment and pathophysiology of microvascular disease: Recent progress and clinical implications

Gloom and doom about addiction and dangers is unlikely to deter them from experimentation but stating the facts in a neutral way and letting them know your own feelings about it could lay the groundwork for responsible decision-making in the future

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