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Molecular dynamics (MD) simulation studies Reason for the selection of specific targets Among all the targets, the SIRT3, FOXO1, and PPARGC1A (PGC-1) were found to have the highest number of edge counts, numerous studies have reported that solely upregulation of SIRT3 can potentiate the activation of FOXO1 (antioxidant-gene) and PGC-1, whereas the activation of FOXO1 downregulates the ROS level, and oxidative stress via mitochondrial access 29,30,31

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