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The PM researchers justified their use of TPM normalization on the grounds that We choose TPM as our basis of comparison to be consistent with the animal and in vitro studies presented in this series of publications and because Since consumers choose to smoke cigarettes according to the tar delivery and taste, we chose to normalize the data to the TPM yield to reveal the effect of ingredients which contribute to the taste [129]

These patients might have other hidden pathologies that would modify the effect of smoking diversely from healthy, fertile men