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NMDA-R blockade So-called dissociative anesthetics, which control pain while maintaining consciousness, were also found to induce gross and temporary psychological symptoms (ie: psychotomimetic effect), including dissociative symptoms (e.g., sensory distortions, derealization, depersonalization)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 212.Bertolini M., Mullen M., Belitsis G., et al

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A comparison of the open and closed conformations of GLUD1 reveals changes in the small helix of the descending strand of the antenna, which seems to recoil as the catalytic cleft opens