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Mn-SOD (SOD2) is a homotetrameric enzyme containing Mn in its active center

Notably, non-invasive test called FIB-4, which combines standard biochemical values (platelets, ALT, AST) and age, exhibited a high performance and demonstrate reasonable sensitivity for the initial screening of advanced hepatic fibrosis in MetALD 72

Key regulatory axesincluding HIF-1, HHIP-PKM2, PTGES-AKT-HIF-1, and lactate/LDH-A (LDH5)-TGF-interact to collectively promote enhanced glycolysis and diminished oxidative metabolism, sustaining the pathological phenotype of the disease ( Abnormalities in the PPP are primarily manifested as oxidative stress-induced compensatory activation

10.1016/j.psychres.2020.113471 3

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