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As one of the main active components of PM, rhein could up-regulate the mRNA and protein levels of Nrf2, HO-1, and glutamate-cysteine ligase catalytic subunit (GCLC), down-regulate the protein expression of NF-B, TNF- and caspase-3, increase the survival rate of LO2 cells, decreasing the apoptosis rate and acting as a hepatoprotective drug (Li et al., 2021b)

The combination aims to restore deficient levels and support the biochemical pathways integral to healthy nerve function and hematopoiesis

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Topical or transdermal application is most common for skin benefits, while injectables may be used under medical supervision

Differences between groups were determined based on a 0.05 significance level ( p )