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In skeletal muscle, these circulating FFAs promote intramyocellular lipid accumulation, disrupting insulin-stimulated glucose uptake through ceramide-mediated inhibition of Akt phosphorylation (376, 377)

HAADF-STEM analysis was performed by an FEI Titan G2 or a JEOL JEM-ARM200 M microscope with an EDX detector

Excessive alcohol consumption can deplete glutathione reserves, impair liver function, and hinder detoxification

When consuming high-fat foods, SREBP-2 is activated and binded to sterol regulatory elements, thereby affecting the expression level of HMG-CoAR (Langston et al., 2005)