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Some inconsistent results in past trials (for cognitive outcomes) may relate to using melatonin in advanced disease stages or issues with absorption in older people

& Bilezikian, J

Studies have shown an upregulation of hexokinase (HK), phosphofructokinase 1 (PFK1), and PKM2 in activated microglia, alongside a significant increase in lactate production, collectively indicating a robust enhancement of glycolysis (Gimeno-Bayn et al., 2014

Beyond cosmetic concerns, the potential anti-ageing effects of ergothioneine in the brain have also been of significant research interest, with in vivo data from animal models showing that ergothioneine protects neurons from damage by cisplatin (72) , -amyloid (73) , and age-related learning and memory deficits (74)