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For skin specifically, this matters because the accumulation of senescent fibroblasts in aging dermis is one of the primary drivers of collagen loss

268 Regulating the protease balance Both endogenous and exogenous Trx inhibit and improve a protease-induced emphysema

doi: 10.1155/2016/2868652, 52

The count data were filtered to remove genes with low expression, transformed using the variance stabilizing transformation from the DESeq2 package (51), and then batch corrected using ComBat (52)