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The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

Gastrointestinal side effects such as nausea, vomiting, and diarrhoea can lead to fluid and electrolyte losses, potentially triggering muscle cramps

Not because oral dosing is impossible, but because the compound's pharmacokinetic profile makes oral bioavailability unreliable for controlled studies