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Roles of glutamine in response to exercise Glutamine is endogenously synthesized from -ketoglutarate, an intermediary metabolite of the citric acid cycle, in two steps mediated by the enzymes glutamate dehydrogenase and glutamine synthetase, that convert -ketoglutarate into glutamate using NADPH and glutamate into glutamine using NH3, respectively [1, 22, 50]

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Some evidence suggests RLS patients may have a defect in iron transport across the blood-brain barrier, possibly related to genetic factors (Wade 2019

& Al-Khalaf, A